Two drug toxidromes, Serotonin syndrome and neuroleptic malignant syndrome, are often confused with each other. The case of a young man who presented with altered mental status, autonomic instability and neuromuscular hyperexcitability was reported.
Serotonin syndrome and NMS are rare but potentially life-threatening adverse reactions to psychotropic medications. The diagnosis of the 2 syndromes is problematic because of Polypharmacy and the similar presentation of NMS.
What is a characteristic of the neuroleptic malignant syndrome?
The syndrome is characterized by high temperature, inflammation of the muscles, and changes in mental status. The components of the nervous system that are malfunctioning lead to wide swings in blood pressure, excessive sweating and saliva production.
Is neuroleptic malignant syndrome the same as tardive dyskinesia?
Tardive dyskinesia is a disorder that can be caused by long-term use of drugs and can cause movements of the jaw, lips and tongue. grimacing, sticking out the tongue, and sucking or fishlike movements of the mouth are some of the typical symptoms. There is a high risk of developing tardive dyskinesia for people who have spent a long time in a mental hospital. If you’re looking for more information abouttardive dyskinesia, you can use the Rare Disease Database.
What is serotonin syndrome?
Serotonin syndrome is a potentially life-threatening drug reaction that can be caused by too much serotonin in the body. Your brain and other parts of your body produce Serotonin, a neurotransmitter.
Do antipsychotics cause serotonin syndrome?
The use of atypical antipsychotics alone doesn’t increase the risk of the disease. Serotonergic agents and atypical antipsychotics can increase the risk of SS. According to the report, physicians should be aware of the risk of developing the disease if they increase the amount of the drug.
Which drug causes neuroleptic malignant syndrome?
The main cause of NMS is dopamine receptor blockade. Potent typical neuroleptics such as haloperidol, fluphenazine, chlorpromazine, trifluoperazine, and prochlorperazine are thought to confer the greatest risk. A number of cases have been reported with most atypical neuroleptics, including risperidone, clozapine, and olanzapine.
What are two signs and symptoms of neuroleptic malignant syndrome?
High or low blood pressure is one of the symptoms of neuroleptic malignant syndrome.
What are the symptoms of serotonin syndrome?
Agitation or insomnia is caused by high blood pressure and high heart rate.
What are the correct symptoms of neuroleptic malignant syndrome NMS )?
Labile blood pressure, tachypnea, tachycardia, sialorrhea, diaphoresis, flushing, skin pallor, and incontinence are some of the signs of autonomic nervous system instability that frequently accompany NMS. Once symptoms appear, progression can be rapid and can reach peak intensity within 3 days. A large number of extrapyramidal motor findings, including tremor, chorea, akinesia, and blepharospasm, have been reported.